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MABE1006 Anti-N6-methyladenosine Antibody (m6A), clone 17-3-4-1

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MABE1006
100 µg  
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      개요

      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      ADB, RIPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE1006
      DescriptionAnti-N6-methyladenosine Antibody (m6A), clone 17-3-4-1
      Alternate Names
      • N6-methyladenosine
      • m6A
      Background InformationN6-Methyladenosine (m6A ) is an abundant modification found in mRNA, tRNA, snRNA, as well as long non-coding RNA, in all species. RNA adenosine methylation is catalyzed by a multicomponent complex composed of METTL3/MT-A70, METTL14, and WTAP in mammals. METTL3 & METTL14 are responsible for the methyltransferase activity of the complex, and WTAP mediates substrate recruitment. Fat mass and obesity-associated (FTO) and ALKBH5 are two identified demethylases that catalyze oxidative demthylation of m6A. Several functions of m6A modification have been proposed, including mRNA decay, splicing regulation, RNA nuclear export and maturation. (PMID 25171402). Cat. No. MABE1006, Anti-N6-methyladenosine (m6A), clone 17-3-4-1, is a mouse monoclonal that specifically detects RNA molecules with m6A modication.
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-N6-methyladenosine Antibody (m6A), clone 17-3-4-1 is an antibody against N6-methyladenosine for use in Dot Blot and RNA binding protein immunoprecipitation.
      Key Applications
      • Dot Blot
      • RNA Binding Protein Immunoprecipitation (RIP)
      Application Notes(RNA) Immunoprecipitation Analysis: A representative lot immunoprecipitated N6-methyladenosine in IME2 transcripts (Bodi, Z., et al. (2010). Nucleic Acids Research. 38(16):5327-5335).
      RNA Dot Blot Analysis: A representative lot detected N6-methyladenosine in m6A (Bodi, Z., et al. (2010). Nucleic Acids Research. 38(16):5327-5335).
      Biological Information
      ImmunogenHapten N6-methyladenosine-5'-mono-phosphate conjugated to BSA of all N6-methyladenosine (m6A).
      EpitopeN6-methyladenosine
      Clone17-3-4-1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1λ
      Species Reactivity
      • All
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G Purified
      Product Usage Statements
      Quality AssuranceEvaluated by RNA Dot Blot in oligomers containing N6-methyladenosine.

      RNA Dot Blot Analysis: 1.0-2.0 μg/mL of this antibody detected N6-methyladenosine in oligomers containing N6-methyladenosine.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABE1006 04055977162707