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MAB4122 Anti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6

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MAB4122
100 µg  
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      개요

      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, WB, IH(P)MCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMAB4122
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6
      Alternate Names
      • MRP
      Product Information
      FormatCulture Supernatant
      PresentationTissue Culture Supernatant. Liquid containing 0.1% sodium azide and 0.7% BSA.
      Quality LevelMQ300
      Applications
      ApplicationAnti-Multi-Drug Resistance Related Protein Antibody, clone MRPm6 is an antibody against Multi-Drug Resistance Related Protein for use in FC, WB, IH(P).
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesWestern blot

      Flow Cytometry

      Immunohistochemistry on frozen and paraffin embedded tissue

      sections: 1:20.

      Note: For cellular detection permeabilization is required.

      Optimal working dilutions must be determined by end user.
      Biological Information
      CloneMRPm6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityMRPm6 reacts with an internal epitope of MRP, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. MRPm6 was raised against a bacterial fusion protein of MRP, containing a segment of 170 amino acids in the carboxy terminal end and part of the carboxy proximal nucleotide binding domain of the protein. MRPm6 does not cross-react with the human MDR1 and MDR3 gene products (Flens et al., 1994).
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms.
      Gene Symbol
      • ABCC1
      • 4transporter)
      • ABC29
      • GS-X
      • ABCC
      • MRP1
      • DKFZp781G125
      • MRP
      • DKFZp686N04233
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P33527 # May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics (By similarity).
      SIZE: 1531 amino acids; 171561 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Lung, testis and peripheral blood mononuclear cells.
      SIMILARITY: SwissProt: P33527 ## Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C in undiluted aliquots. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      카탈로그 번호 GTIN
      MAB4122 04053252358197