204903
Anti-Complement 5b-9 Rabbit pAb
liquid, Calbiochem®
동의어(들):
Anti-Terminal Complement Complex, Anti-Membrane Attack Complex, Anti-MAC
제품 이름
Anti-Complement 5b-9 Rabbit pAb, liquid, Calbiochem®
biological source
rabbit
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
dilution
(Frozen Sections
Immunofluorescence
Paraffin Sections (heat pre-treatment required)
Radial Immunodiffusion (use undiluted))
isotype
IgG
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Application
Frozen Sections (see application references)
Immunofluorescence (see comments)
Paraffin Sections (see comments, heat pre-treatment required)
Radial Immunodiffusion (use undiluted)
Immunofluorescence (see comments)
Paraffin Sections (see comments, heat pre-treatment required)
Radial Immunodiffusion (use undiluted)
Disclaimer
Toxicity: Standard Handling (A)
General description
Protein A purified rabbit polyclonal antibody. Recognizes the C5b-C9 complement component complex.
Recognizes complement component complex Cb5-C9.
This Anti-Complement 5b-9 Rabbit pAb is validated for use in Frozen Sections, Immunofluorescence, Paraffin Sections, Radial Immunodiffusion for the detection of Complement 5b-9.
Immunogen
Human
purified human SC5b-9 complex
Other Notes
By immunodiffusion the antibody is monospecific for C5b-9 complex in purified form or present in cobra venom factor activated human serum. There is no reactivity vs. non-activated normal human serum or plasma. Also reported to work for immunofluorescence. This antibody has been shown to work for formalin-fixed paraffin sections; use of citrate buffer and a pressure cooker for 1 min is required for antigen retrieval. Antibody should be titrated for optimal results in individual systems.
Schafer, H., et al. 1986. J. Immunol.137, 1945.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In PBS, pH 7.2.
Preparation Note
Following intial thaw, aliquot and freeze (-20°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Jean F Regal et al.
Molecular immunology, 78, 38-47 (2016-09-03)
Preeclampsia is characterized by development of hypertension during pregnancy and reduced placental perfusion. Previous studies in a rat model of placental ischemia-induced hypertension demonstrated that inhibiting complement activation attenuated increased maternal blood pressure with C3a and C5a identified as the
Melina V Jones et al.
Journal of immunology research, 2018, 9034695-9034695 (2019-01-17)
To reduce immune-mediated damage in a rat model of neuromyelitis optica (NMO) by blocking neutrophil migration using SCH527123, a drug that inhibits CXCR2. Neuromyelitis optica is a relapsing autoimmune disease that preferentially targets the optic nerves and spinal cord leading
Elena Panayiotou et al.
PloS one, 12(4), e0175767-e0175767 (2017-04-14)
ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation co-localizes
E Panayiotou et al.
Biochemistry and biophysics reports, 8, 48-54 (2017-09-29)
Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice
Mohammed Alshareef et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Germinal matrix hemorrhage (GMH) is a pathology that occurs in infancy, with often devastating long-term consequences. Posthemorrhagic hydrocephalus (PHH) can develop acutely, while periventricular leukomalacia (PVL) is a chronic sequala. There are no pharmacological therapies to treat PHH and PVL.
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 204903-1MGCN | 04055977219876 |
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