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MABS458 Anti-Betacellulin Antibody, clone 6G10.1

This Anti-Betacellulin Antibody, clone 6G10.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of Betacellulin .

Anti-Betacellulin Antibody, clone 6G10.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: BTC UniProt Number: P35070
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MABS458
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS458
      Description Anti-Betacellulin Antibody, clone 6G10.1
      Alternate Names
      • Probetacellulin
      • Betacellulin
      • BTC
      Background InformationThe human BTC gene (Gene ID 685) encodes the 178 aa preprobetacellulin (UniProt P35070) protein. Post-translatioinal removal of the signal peptide (aa 1-31) produces probetacellulin (aa 32-178), which further matures into the 80 aa betacellulin (aa 32-111) following propeptide (aa 112-178) removal. Betacellulin is an EGF family growth factor with a higher affinity and specificity for ErbB1/EGFR and ErbB4. Betacellulin plays an important role in the development of the acute exacerbations of chronic obstructive pulmonary disease. Betacellulin is also reported to induce CXCL8 (IL-8) production from human lung cancer cells through EGFR–PI3K–Akt–ERK pathway activation, resulting in the recruitment of inflammatory cells in the cancer tissue and creating an inflammatory tumor microenvironment.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Betacellulin Antibody, clone 6G10.1 is validated for use in Western Blotting, Immunohistochemistry for the detection of Betacellulin .
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Betacellulin in human pancreas tissue.
      Biological Information
      ImmunogenGST-tagged human recombinant full-length mature betacellulin.
      EpitopeMature betacellulin
      Clone6G10.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6G10.1 is expected to detect prepro-, pro-, and mature betacellulin.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • BTC
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~20 kDa observed. Preprobetacellulin (19.7 kDa calculated); Probetacellulin (16.6 kDa calculated); Betacellulin (9.0 kDa calculated). Due to posttranslational glycosylation, target band(s) will migrate with a higher apparent M.W. than caluclated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human pancreas tissue lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Betacellulin in 10 µg of human pancreas tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABS458 04055977175448