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ABN445 Anti-ARL13B Antibody

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ABN445
100 µg  
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      개요

      Replacement Information

      주요 사양표

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN445
      DescriptionAnti-ARL13B Antibody
      Alternate Names
      • ARL13B
      • ARL2-like protein 1
      • ADP-ribosylation factor-like protein 13B
      • ADP-ribosylation factor-like protein 2-like 1
      Background InformationARL13B/ARL2L1 is an important neuronal developmental protein, as well as, a cilium-specific protein required for the control of the microtubule-based ciliary axoneme structure. ARL13B/ARL2L1 is required for proper patterning in neural development during neural tube formation, and ARL13B/ARL2L1 is critical for cerebral cortex development and the initial polarization of radial glia scaffold, the first step in cortex development. ARL13B/ARL2L1 also controls the migration and placement of post mitotic interneurons. ARL13B/ARL2L1 is found in cellular projections and cilium and is widely expressed in the developing system as well in the gut. ARL13B/ARL2L1 also is a member of the small GTPase superfamily as it binds GTP but does not cleave it.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-ARL13B Antibody is an antibody against ARL13B for use in Immunohistochemistry and Immunocytochemistry.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ARL13B in human cerebellum, embryonic mouse liver, and human cerebral cortex tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human ARL13B.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Mouse
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARL13B
      • ARL2L1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~60 kDa observed. Western blot shows the absence of a 60 kDa Arl13b band in Arl13bE9.5 (Humbert, M.C., et al. (2012). PNAS. 109(48):19691-19696).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse E13-14 brain tissue lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected ARL13B in 10 µg of mouse E13-14 brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      ABN445 04055977135268

      Documentation

      Anti-ARL13B Antibody MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Anti-ARL13B Antibody Certificates of Analysis

      TitleLot Number
      Anti-ARL13B - 3279692 3279692
      Anti-ARL13B - 4182416 4182416
      Anti-ARL13B -Q2550845 Q2550845

      References

      Reference overviewPub Med ID
      Proceedings of the National Academy of Sciences of the United States of America
      Humbert, MC; Weihbrecht, K; Searby, CC; Li, Y; Pope, RM; Sheffield, VC; Seo, S
      Proceedings of the National Academy of Sciences of the United States of America  109  19691-6  2012

      요약 표시
      23150559 23150559

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.