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MABS2169-100UL Anti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA) Antibody, clone 6H

Anti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA), clone 6H, Cat. No. MABS2169, is a mouse monoclonal antibody that detects 3-monoglucuronyl glycyrrhetinic acid (3MGA) and is tested ELISA.

MABS2169-100UL
100 µL  
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      개요

      Replacement Information
      Description
      Catalogue NumberMABS2169-100UL
      DescriptionAnti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA) Antibody, clone 6H
      Background Information3-monoglucuronyl glycyrrhetinic acid (3-MGA) is one of the metabolites of glycyrrhizin (GL) contained in licorice. It is reported to cause licorice-induced pseudoaldosteronism. It acts as an inhibitor of 11 beta-hydroxysteroid dehydrogenase, which allows cortisol to exert its full mineralocorticoid effects. Orally ingested GL is metabolized to 3-MGA and glycyrrhetinic acid (GA) by intestinal bacteria and subsequently 3-MGA is absorbed into the blood stream. Only a small fraction of absorbed GA is transformed to 3MGA in the liver by UDP-glucuronyltransferase. Circulating GA is metabolized in the liver to 3-MGA, which is excreted into the bile via multi-drug resistance protein 2 (Mrp2). However, if Mrp2 function is damaged then 3-MGA is secreted from the liver into the circulation and excreted into the urine via organic anion transporters. It is reported that circulating GA cannot be excreted into the urine since GA binds highly to serum albumin and thus does not pass through glomerular filtration and is not a substrate of transporters expressed on tubular epithelial cells. 3-MGA has a long plasma half-life and can cause hypokalemia. Clone 6H is suitable for detection of 3-MGA by ELISA and exhibits only minimal cross-reactivity with GA and GL. (Ref.: Kato, H., et al. (1995). J. Clin. Endocrinol. Metab. 80(6); 1929-1933; Makino, T (2014). Biol. Pharma. Bulletin. 37(6); 898-902; Morinaga, O., et al. (2018). Sci. Rep. 8; 15568).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA), clone 6H, Cat. No. MABS2169, is a mouse monoclonal antibody that detects 3-monoglucuronyl glycyrrhetinic acid (3MGA) and is tested ELISA.
      Key Applications
      • ELISA
      Application NotesELISA Analysis: A representative lot detected 3-Monoglucuronyl Glycyrrhetinic acid (3-MGA) in ELISA applications (Morinaga, O., et. al. (2018). Sci Rep. 8(1):15568).

      ELISA Analysis: 1 µg/mL from a representative lot detected 3-Monoglucuronyl Glycyrrhetinic acid (3-MGA) (Courtesy of Prof. Osamu Morinaga, Ph.D., Daiichi University of Pharmacy, Fukuoka, Japan).
      Biological Information
      ImmunogenKLH-conjugate of 3-Monoglucuronyl Glycyrrhetinic acid (3-MGA).
      Clone6H
      HostMouse
      SpecificityClone 6H is a mouse monoclonal antibody that detects 3-Monoglucuronyl Glycyrrhetinic acid (3-MGA).
      IsotypeIgG2aκ
      Species Reactivity
      • All
      Species Reactivity NoteAll.
      Antibody TypeMonoclonal Antibody
      Purification MethodProtein G purified
      Molecular Weight646.8 Da for 3-MGA
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceIsotype testing: Identity Confirmation by Isotyping Test.

      Isotyping Analysis: The identity of this monoclonal antibody is confirmed by isotyping test to be mouse IgG2a.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      MABS2169-100UL 04061841588351

      Documentation

      Anti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA) Antibody, clone 6H MSDS

      타이틀

      물질안전보건자료(MSDS) 

      Anti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA) Antibody, clone 6H Certificates of Analysis

      TitleLot Number
      Anti-3-Monoglucuronyl Glycyrrhetinic acid (3-MGA), clone 6H - Q3430096 Q3430096

      References

      Reference overviewPub Med ID
      Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism.
      Morinaga, O; Ishiuchi, K; Ohkita, T; Tian, C; Hirasawa, A; Mitamura, M; Maki, Y; Yasujima, T; Yuasa, H; Makino, T
      Sci Rep  8  15568  2018

      요약 표시       		30348944 30348944