124029 Sigma-AldrichAkt Inhibitor XII, Isozyme-Selective, Akti-2 - Calbiochem
Akt Inhibitor XII, Isozyme-Selective, Akti-2, is a cell-permeable, selective inhibitor of Akt2 (IC50 = 805 nM). The inhibition is PH domain-dependent and non-competitive with ATP.
More>> Akt Inhibitor XII, Isozyme-Selective, Akti-2, is a cell-permeable, selective inhibitor of Akt2 (IC50 = 805 nM). The inhibition is PH domain-dependent and non-competitive with ATP. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and
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개요
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주요 사양표
| Empirical Formula |
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| C₃₉H₃₉N₇O₂ • 3HCl |
가격 및 재고여부
| 카탈로그 번호 | 재고 정보 | 패킹 | 포장 단위 | 가격(VAT 별도) | 수량 | |
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| 124029-2MGCN |
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Glass bottle | 2 mg |
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| Description | |
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| Overview | A cell-permeable Akti-1/2- (Cat. No. 124018) derived allosteric inhibitor pair (1:1 regioisomeric mixture) with much improved aqueous solubility (10 mg/ml in a pH 7.4 saline) and Akt2 selectivity (IC50 = 805 nM for Akt2, >10 µM for Akt1/3, and >50 µM for PKA/PKC/SGK). The inhibition is PH domain-dependent and non-competitive with ATP. |
| Catalogue Number | 124029 |
| Brand Family | Calbiochem® |
| Synonyms | 1-((3-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-2-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl, 1-((2-(4-((4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl)methyl)phenyl)-3-phenyl-6-quinoxalinyl)carbonyl)-4-methyl-piperazine, 3HCl and |
| References | |
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| References | Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49. |
| Product Information | |
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| Form | Yellow solid |
| Hill Formula | C₃₉H₃₉N₇O₂ • 3HCl |
| Chemical formula | C₃₉H₃₉N₇O₂ • 3HCl |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Purity | ≥97% by HPLC (mixture of regioisomers) |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 카탈로그 번호 | GTIN |
| 124029-2MGCN | 04055977205763 |
Documentation
Akt Inhibitor XII, Isozyme-Selective, Akti-2 - Calbiochem MSDS
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Akt Inhibitor XII, Isozyme-Selective, Akti-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 124029 |
References
| 참고문헌 보기 |
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| Zhao, Z., et al. 2008. Bioorg. Med. Chem. Lett. 18, 49. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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