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208719 ALLN - CAS 110044-82-1 - Calbiochem

ALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).

ALLN - CAS 110044-82-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V

Primary Target: Calpain-1
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208719
가격 및 재고 조회

개요

Replacement Information

주요 사양표

CAS #Empirical Formula
110044-82-1C₂₀H₃₇N₃O₄

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
208719-25MGCN
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      		 Plastic ampoule 25 mg
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      208719-5MGCN
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          		 Plastic ampoule 5 mg
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          Description
          OverviewCell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and the proteasome (Ki = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
          Catalogue Number208719
          Brand Family Calbiochem®
          SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
          References
          ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Product Information
          CAS number110044-82-1
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₂₀H₃₇N₃O₄
          Chemical formulaC₂₀H₃₇N₃O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationALLN, CAS 110044-82-1, is a cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
          Biological Information
          Primary TargetCalpain-1
          Primary Target K<sub>i</sub>190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          카탈로그 번호 GTIN
          208719-25MGCN 04055977202656
          208719-5MGCN 04055977202663

          Documentation

          ALLN - CAS 110044-82-1 - Calbiochem MSDS

          타이틀

          물질안전보건자료(MSDS) 

          ALLN - CAS 110044-82-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          208719

          References

          참고문헌 보기
          Debiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Proteasomes Technical Bulletin

          Citations

          타이틀
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsLLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V
          DescriptionInhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). Inhibits neutral cysteine proteases and proteasome (Ki = 6 µM). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. Inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex.
          FormWhite to off-white solid
          CAS number110044-82-1
          Chemical formulaC₂₀H₃₇N₃O₄
          Peptide SequenceN-Acetyl-Leu-Leu-Nle-CHO
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesDebiasi, R.L., et al. 1999. J. Virol. 73, 695.
          Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
          Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
          Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
          Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
          Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Citation
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
          		•

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          카테고리

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Proteasome and Ubiquitination Pathway Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors