수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
			96-Well Plate

수량	카탈로그 번호	주문 설명	포장 단위	기재 가격
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

128136 Sigma-Aldrich7α, 25-dihydroxycholesterol - CAS 64907-22-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC

Recommended Products

개요

Replacement Information

주요 사양표

CAS #	Empirical Formula
64907-22-8	C₂₇H₄₆O₃

가격 및 재고여부

카탈로그 번호	재고 정보	패킹	포장 단위	가격(VAT 별도)	수량
128136-1MGCN	재고 정보 검색... — 현재 재고 없음 예상 출고 가능일 단종품 제한된 수량 가능 재고여부 확인 재고목록을 보려면 로그인하십시오 예상 출고 가능일 현재 재고 없음 예상 출고 가능일 Remaining: will advise Remaining: will advise 추천사항 고객 서비스로 문의 Contact Customer Service 고객 서비스로 문의 고객 서비스로 문의	Glass bottle	1 mg	가격 검색... 가격을 검색할 수 없습니다 Minimum Quantity needs to be mulitiple of Maximum Quantity is 가격 문의 추가 정보 ()이 할인됨 — 가격 문의 고객님의 가격을 보려면 로그인하십시오	재고 조회 —	즐겨찾기에 추가 즐겨찾기에 추가 나의 즐겨찾기에 추가

Description
Overview	A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450 pM in a saturation binding analysis, and activates EBI2 (EC₅₀=140 pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-γ assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-β galactosidase cell line with an IC₅₀ of 2 nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice.
Catalogue Number	128136
Brand Family	Calbiochem®
Synonyms	EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC

References
References	Liu, C., et al. 2011. Nature 475, 519.

Product Information
CAS number	64907-22-8
Form	White powder
Hill Formula	C₂₇H₄₆O₃
Chemical formula	C₂₇H₄₆O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
카탈로그 번호	GTIN
128136-1MGCN	04055977222227

Documentation

7α, 25-dihydroxycholesterol - CAS 64907-22-8 - Calbiochem MSDS

타이틀
물질안전보건자료(MSDS)

7α, 25-dihydroxycholesterol - CAS 64907-22-8 - Calbiochem Certificates of Analysis

Title	Lot Number
128136	로트(lot) 번호를 입력하십시오.

References

참고문헌 보기
Liu, C., et al. 2011. Nature 475, 519.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-February-2013
Synonyms	EBI2 agonist, EBI2 Activator, GPR183 Activator, 7alpha,25-OHC
Description	A highly potent and specific oxysterol EBI2 (GPR183) agonist with a kd of 450 pM in a saturation binding analysis, and activates EBI2 (EC₅₀=140 pM compared with 2.1nM for its enantiomer 7b,25-OHC) in a GTP-γ assay. Dose-dependenty suppresses forskolin-induced cAMP accumulation in EBI2-expressing SK-N-MC/CRE-β galactosidase cell line with an IC₅₀ of 2 nM, but not in control cells. Stimulates migration of LPS-activated spleen B cells and T cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells from EBI2-deficient mice.
Form	White powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	64907-22-8
Chemical formula	C₂₇H₄₆O₃
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (25 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Liu, C., et al. 2011. Nature 475, 519.

카테고리

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > G-Protein Coupled Receptor Agonists

해당 제품은 고객님의 카트에 추가되었습니다.