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401003 (±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

A nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC₅₀ = 4.85 µM).

(±)-Ibuprofen - CAS 15687-27-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [(±)-2-(4-Isobutylphenyl)-propionic Acid

Primary Target: COX-1
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401003
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개요

주요 사양표

CAS #Empirical Formula
15687-27-1C₁₃H₁₈O₂

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      Description
      OverviewA nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 µM). Inhibits COX-2 at higher concentrations (IC50 = 223 µM). Blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β40 and 42) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM).
      Catalogue Number401003
      Brand Family Calbiochem®
      Synonyms[(±)-2-(4-Isobutylphenyl)-propionic Acid
      References
      ReferencesAsanuma, M., et al. 2001. J. Neurochem. 76, 1895.
      Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
      Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
      Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
      Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
      Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
      Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
      Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
      Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
      Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
      Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.
      Product Information
      CAS number15687-27-1
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₃H₁₈O₂
      Chemical formulaC₁₃H₁₈O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>4.85 µM against COX-1
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSMU6640000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      카탈로그 번호 GTIN
      401003-1GMCN 04055977189377