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203980 α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem

Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings.

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203980
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개요

Replacement Information

주요 사양표

CAS #Empirical Formula
11032-79-4C₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁

가격 및 재고여부

카탈로그 번호 재고 정보패킹 포장 단위 가격(VAT 별도) 수량
203980-1MGCN
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      		 Plastic ampoule 1 mg
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      Description
      OverviewBlocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 µM).
      Catalogue Number203980
      Brand Family Calbiochem®
      References
      ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.
      Product Information
      CAS number11032-79-4
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMotor end-plate acetylcholine receptor
      Primary Target IC<sub>50</sub>Kd = 1 pM to 1 nM for motor end-plate acetylcholine receptor
      Physicochemical Information
      Cell permeableN
      ContaminantsNone detectable by IEF. Supplied as an acetate salt
      Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEI6201400
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      카탈로그 번호 GTIN
      203980-1MGCN 04055977219944

      Documentation

      α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem MSDS

      타이틀

      물질안전보건자료(MSDS) 

      α-Bungarotoxin, Bungarus multicinctus - CAS 11032-79-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      203980

      References

      참고문헌 보기
      Lopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionA polypeptide composed of 74 amino acids containing 5 disulfide bridges. Blocks neuromuscular transmission by irreversible binding to the motor end-plate acetylcholine receptor (Kd = 1 nM to 1 pM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced augmentation in intracellular Ca2+ in PC12 cells (IC50 = 310 nM). Prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-Bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 > 3 µM).
      FormLyophilized solid
      CAS number11032-79-4
      RTECSEI6201400
      Chemical formulaC₃₃₈H₅₂₉N₉₇O₁₀₅S₁₁
      Peptide SequenceH-Ile-Val-Cys³-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys¹⁶-Pro-Pro-Gly-Glu-Asn-Leu-Cys²³-Tyr-Arg-Lys-Met-Trp-Cys²⁹-Asp-Ala-Phe-Cys³³-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys⁴⁴-Ala-Ala-Thr-Cys⁴⁸-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys⁵⁹-Cys⁶⁰-Ser-Thr-Asp-Lys-Cys⁶⁵-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly-OH (disulfide bonds: 3 → 23; 16 → 44; 29 → 33; 48 → 59; 60 → 65)
      ContaminantsNone detectable by IEF. Supplied as an acetate salt
      SolubilityH₂O or PBS
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 1488
      ReferencesLopez, M.G., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14184.
      Zhang, Z.W., et al. 1994. Neuron 12, 167.
      Bambrick, L.L., and Gordon, T. 1992. J. Physiol. 449, 479.
      Lin, S.R., and Chang, C.C. 1992. Biochim. Biophys. Acta 1159, 255.
      Motomura, M., et al. 1992. Neurosci. Lett. 143, 139.
      Sorenson, E.M., and Chiappinelli, V.A. 1992. J. Comp. Neurol. 323, 1.
      Ruan, K.H., et al. 1990. 87, 6156.