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Optimized TRIS now available in new purity grade

Issue: June 20, 2013
| Category: Downstream, Upstream




In our book, the best way to improve performance is by avoiding complacency, and continuously monitoring and challenging your own processes. Take TRIS, for example – a buffer for pH adjustments in downstream purification. During research following a customer notification, our attention was drawn to a substance we identified as polyoxymethylene dimethylether (POM), a by-product formed in the synthesis of TRIS.

In highly concentrated TRIS solutions, this by-product can lead to deposits. So we adjusted our raw material selection process for TRIS accordingly, and developed a recrystallization procedure that limits total POM levels in TRIS to just 90 ppm. As a result, the vast majority of the deposits in question have now been eliminated. You can detect the by-product by means of photometric analysis – for example with our Spectroquant® system.

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