On-Demand Webinar

Microcarriers in Single-use Culturing of Adherent Cells

Duration: 1 Hour
Speaker: Lee Madrid, Ph.D., Senior Consulting Engineer, Merck

Abstract: This webinar will discuss the cultivation of adherent mammalian cells on microcarriers utilizing our 3L and 50L Mobius® CellReady single-use stirred tank bioreactors. We will outline how Cytodex® and Solohill® collagen coated microcarriers were tested as part of a mixing study to assess feasibility of the mixing system under various power per unit volume conditions. We will then present our evaluation of the normalized mixing speeds required by the 3L and 50L bioreactors to achieve a suspension of the microcarriers. In addition, we will demonstrate how the bioreactors enabled efficient growth of Madin-Darby Canine Kidney Cells (MDCK), a cell line traditionally used in influenza vaccine production, as well as Human Mesenchymal Stem Cells (hMSCs).

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