1.11474
1,4-Dithiothreitol
for biochemistry
Synonym(s):
1,4-Dithiothreitol, DTT, Cleland’s reagent
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About This Item
Product Name
1,4-Dithiothreitol, for biochemistry
SMILES string
SC[C@H](O)[C@@H](O)CS
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1
InChI key
VHJLVAABSRFDPM-IMJSIDKUSA-N
assay
≥99% (iodometric)
form
solid
potency
400 mg/kg LD50, oral (Rat)
reaction suitability
reagent type: reductant
pH
5.1 (20 °C, 10 g/L in H2O)
mp
40-43 °C
transition temp
flash point >110 °C
bulk density
300 kg/m3
storage temp.
2-8°C
Quality Level
Analysis Note
Identity (IR-spectrum): passes test
Melting point: 40 - 43 °C
Heavy metals (as Pb): ≤ 10 ppm
Fe (Iron): ≤ 5 ppm
Application
- Drug delivery using reduction-responsive hydrogel based on carboxyethyl-succinoglycan with highly improved rheological, antibacterial, and antioxidant properties.: This study explores the application of 1,4-Dithiothreitol in developing reduction-responsive hydrogels, highlighting significant enhancements in rheological, antibacterial, and antioxidant characteristics, suitable for drug delivery systems (Kim et al., 2024).
- Preparation and properties of hydrogel photonic crystals assembled by biodegradable nanogels.: Research discusses the integration of 1,4-Dithiothreitol in the assembly of hydrogel photonic crystals using biodegradable nanogels, emphasizing their potential in creating novel photonic materials (Zhang et al., 2024).
- Optimized total RNA isolation from bovine sperm with enhanced sperm head lysis.: The paper highlights the use of 1,4-Dithiothreitol in optimizing RNA isolation techniques from bovine sperm, which enhances sperm head lysis, crucial for reproductive biology studies (Tiwari et al., 2024).
- Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides.: Discusses the synthesis of a convertible spacer containing a disulfide group using 1,4-Dithiothreitol, enabling versatile functionalization of oligonucleotides for therapeutic and diagnostic applications (Pontarelli et al., 2023).
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 1.11474.0025 | 04022536133096 |
| 1.11474.0001 | 04022536133072 |
| 1.11474.0005 | 04022536133089 |
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