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Merck

1.00399

N,N-Dimethylacetamide

for headspace gas chromatography SupraSolv®

Synonym(s):

N,N-Dimethylacetamide, Acetic acid dimethylamide, Acetyldimethylamine, DMAC, DMA, DMA

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About This Item

Linear Formula:
CH3CON(CH3)2
CAS Number:
127-19-5
Molecular Weight:
87.12
UNSPSC Code:
12352111
EC Index Number:
204-826-4
NACRES:
NA.03
MDL number:
MFCD00008686
Assay:
≥99.8% (GC)
Technique(s):
GC-HS: suitable
Bp:
165-166 °C/1013 hPa
Vapor pressure:
1.76 hPa ( 20 °C)

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SMILES string

N(C)(C)C(=O)C

InChI

1S/C4H9NO/c1-4(6)5(2)3/h1-3H3

InChI key

FXHOOIRPVKKKFG-UHFFFAOYSA-N

vapor pressure

1.76 hPa ( 20 °C)

product line

SupraSolv®

assay

≥99.8% (GC)

form

liquid

autoignition temp.

400 °C

potency

5830 mg/kg LD50, oral (Rat)

expl. lim.

1.7-11.5 % (v/v)

technique(s)

GC-HS: suitable

pH

4 (20 °C, 200 g/L in H2O)

bp

165-166 °C/1013 hPa

mp

-20 °C

transition temp

flash point 64 °C

solubility

soluble >1000 g/L

density

0.94 g/cm3 at 20 °C

storage temp.

2-30°C

Quality Level

100

Related Categories

General description

SupraSolv® high-purity solvents for headspace gas chromatography (HS-GC) are developed particularly for the analysis of residual solvents (RS) in drug substances, excipients and drug products according to ICH (International Council for Harmonizaton of Technical Requirements for Registration of Pharmaceuticals for Human Use) Guideline Q3C»Impurities: Guideline for Residual Solvents«, European Pharmacopeia (Ph. Eur. Chapter 2.4.24) and United States Pharmacopeia (USP Chapter 467).

Application

Suitable as a solvent for analysis of residual solvents of ICH classes 1, 2 and 3 according to Ph. Eur. and USP:

  • Every residual solvent of class 1 acc. ICH ≤ 1 µg/g
  • Every residual solvent of class 2 acc. ICH ≤ 10 µg/g
  • Every residual solvent of class 3 acc. ICH ≤ 50 µg/g

Features and Benefits

  • high application reliability due to the application test performed on every batch produced
  • application-oriented quality due to specified concentrations of residual solvents as defined by ICH

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markHealth hazard
GHS07,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

147.2 °F - closed cup

flash_point_c

64 °C - closed cup

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
1.00399.100004027269256135

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