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691550 Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
15442-64-5C₃₄H₃₂N₄O₄Zn

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691550-25MGCN
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      Description
      OverviewA potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
      Catalogue Number691550
      Brand Family Calbiochem®
      SynonymsZnPP-9
      References
      ReferencesWolff, D.J., et al. 1996. Arch. Biochem. Biophys. 333, 27.
      Bing, O., et al. 1995. NeuroReport 6, 1369.
      Hinchliffe, R.F., et al. 1995. Pediatr. Hematol. Oncol. 12, 455.
      Kadoya, C., et al. 1995. Stroke 26, 1035.
      Ny, L., et al. 1995. Br. J. Pharmacol. 115, 186.
      Luo, D., and Vincent, S.R. 1994. Eur. J. Pharmacol. 267, 263.
      Marks, G.S., et al. 1993. Can. J. Physiol. Pharmacol. 71, 753.
      Zhuo, M., et al. 1993. Science 260, 1946.
      Product Information
      CAS number15442-64-5
      ATP CompetitiveN
      FormDark red solid
      Hill FormulaC₃₄H₃₂N₄O₄Zn
      Chemical formulaC₃₄H₃₂N₄O₄Zn
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetheme oxygenase
      Primary Target IC<sub>50</sub> 800 nM, 4 µM, and 5 µM for nNOS, iNOS, and eNOS, respectively
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
      Global Trade Item Number
      Catalogue Number GTIN
      691550-25MGCN 04055977225143