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681667 Wnt Agonist II, SKL2001 - CAS 909089-13-0 - Calbiochem

Wnt Agonist II, SKL2001, CAS 909089-13-0, upregulates β-catenin-regulated transcription by disrupting β-catenin & Axin interaction. Prevents β-catenin phosphorylation and proteasomal degradation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII

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681667
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
909089-13-0C₁₄H₁₄N₄O₃

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      Description
      OverviewA cell-permeable imidazolyl-isoxazolamide that upregulates β-catenin-regulated transcription (CRT; 10 - 40 µM) by disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).
      Catalogue Number681667
      Brand Family Calbiochem®
      Synonyms5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
      References
      ReferencesGwak, J., et al. 2012. Cell Res. 22, 237.
      Product Information
      CAS number909089-13-0
      FormPinkish red solid
      Hill FormulaC₁₄H₁₄N₄O₃
      Chemical formulaC₁₄H₁₄N₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationWnt Agonist II, SKL2001, CAS 909089-13-0, upregulates β-catenin-regulated transcription by disrupting β-catenin & Axin interaction. Prevents β-catenin phosphorylation and proteasomal degradation.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      681667-25MGCN 04055977260250

      Documentation

      Wnt Agonist II, SKL2001 - CAS 909089-13-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Wnt Agonist II, SKL2001 - CAS 909089-13-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      681667

      References

      Reference overview
      Gwak, J., et al. 2012. Cell Res. 22, 237.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-October-2012 JSW
      Synonyms5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
      DescriptionA cell-permeable imidazolyl-isoxazolamide compound that upregulates β-catenin-regulated transcription (CRT; Effective conc. 10 - 40 µM) by blocking/disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Wnt pathway activation by SKL2001 is shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).
      FormPinkish red solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number909089-13-0
      Chemical formulaC₁₄H₁₄N₄O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml; clear, red solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGwak, J., et al. 2012. Cell Res. 22, 237.