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681535 Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
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681535
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
5119-48-2C₂₈H₃₈O₆

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681535-1MGCN
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      681535-5MGCN
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          Description
          OverviewA cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
          Catalogue Number681535
          Brand Family Calbiochem®
          References
          ReferencesMohan, R., et al. 2004. Angiogenesis 7, 115.
          Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
          Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
          Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.
          Product Information
          CAS number5119-48-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₈H₃₈O₆
          Chemical formulaC₂₈H₃₈O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetA steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
          Primary Target IC<sub>50</sub>12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSKE7288500
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          681535-1MGCN 04055977260113
          681535-5MGCN 04055977260120

          Documentation

          Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem Certificates of Analysis

          TitleLot Number
          681535

          References

          Reference overview
          Mohan, R., et al. 2004. Angiogenesis 7, 115.
          Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
          Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
          Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-September-2008 RFH
          DescriptionA cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC50 = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number5119-48-2
          RTECSKE7288500
          Chemical formulaC₂₈H₃₈O₆
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesMohan, R., et al. 2004. Angiogenesis 7, 115.
          Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125.
          Devi, P.U., et al. 1995. Cancer Lett. 95, 189.
          Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.