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648469 Troglitazone - CAS 97322-87-7 - Calbiochem

A α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ).

Troglitazone - CAS 97322-87-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Peroxisome proliferator-activated receptors γ (PPARγ)
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648469
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
97322-87-7C₂₄H₂₇NO₅S

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648469-5MGCN
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      Description
      OverviewA α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMC) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21Cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in the sarcoplasmic reticulum and inhibits Na+/H+ exchange activity and proliferation of macrovascular endothelial cells.
      Catalogue Number648469
      Brand Family Calbiochem®
      References
      ReferencesMasamune, A., et al. 2002. J. Biol. Chem. 277, 141.
      Boyault, S., et al. 2001. FEBS Lett. 501, 24.
      de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
      Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
      Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
      Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
      Koga, H., et al. 2001. Hepatology 33, 1087.
      Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
      Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
      Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
      Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
      Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
      Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.
      Product Information
      CAS number97322-87-7
      ATP CompetitiveN
      FormWhite to yellow solid
      Hill FormulaC₂₄H₂₇NO₅S
      Chemical formulaC₂₄H₂₇NO₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPeroxisome proliferator-activated receptors γ (PPARγ)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXJ5813130
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      648469-5MGCN 04055977262469

      Documentation

      Troglitazone - CAS 97322-87-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Troglitazone - CAS 97322-87-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      648469

      References

      Reference overview
      Masamune, A., et al. 2002. J. Biol. Chem. 277, 141.
      Boyault, S., et al. 2001. FEBS Lett. 501, 24.
      de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
      Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
      Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
      Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
      Koga, H., et al. 2001. Hepatology 33, 1087.
      Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
      Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
      Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
      Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
      Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
      Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-March-2018 JSW
      DescriptionA α-tocopherol (vitamin E) moiety containing thiazolidinedione class of insulin-sensitizer that acts as an activator of peroxisome proliferator-activated receptors γ (PPARγ). Also exhibits anti-proliferative and anti-inflammatory properties. Shown to induce cell cycle arrest and apoptosis in human hepatoma cells. Inhibits vascular smooth muscle cell (VSMCs) migration by rapidly activating MEK/ERK pathway leading to the induction of c-fos and Ets-1 expression. Blocks PDGF-induced cell proliferation of pancreatic stellate and accelerates p21cip1 turnover by inhibiting PKCδ signaling in VSMCs. Exerts positive inotropic effect via Ca2+ sensitization in sarcoplasmic reticulum and inhibits Na+/H+ change activity.
      FormWhite to yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number97322-87-7
      RTECSXJ5813130
      Chemical formulaC₂₄H₂₇NO₅S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMasamune, A., et al. 2002. J. Biol. Chem. 277, 141.
      Boyault, S., et al. 2001. FEBS Lett. 501, 24.
      de Dios, S.T., et al. 2001. J. Diabetes Complications 15, 120.
      Furuse, Y., et al. 2001. Br. J. Pharmacol. 133, 1307.
      Ghanim, H., et al. 2001. J. Clin. Endocrinol. Metab. 86, 1306.
      Goetze, S., et al. 2001. J. Cardiovasc. Pharmacol. 38, 909.
      Koga, H., et al. 2001. Hepatology 33, 1087.
      Rosen, E.D. and Spiegelman, B.M., 2001. J. Biol. Chem. 276, 37731.
      Subbaramaiah, K., et al. 2001. J. Biol. Chem. 276, 12440.
      Takashima, T., et al. 2001. Int. J. Oncol. 19, 465.
      Takeda, K., et al. 2001. J. Biol. Chem. 276, 48950.
      Tanaka, T., et al. 2001. Cancer Res. 61, 2424.
      Wakino, S., et al. 2001. J. Biol. Chem. 276, 47650.