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616521 TRPV4 Antagonist II, HC-067047 - CAS 883031-03-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
883031-03-6C₂₆H₂₈F₃N₃O₂

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616521-10MGCN
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      Description
      OverviewA pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780 nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo.
      Catalogue Number616521
      Brand Family Calbiochem®
      Synonyms2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047
      References
      ReferencesEveraerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 19084.
      Product Information
      CAS number883031-03-6
      FormWhite solid
      Hill FormulaC₂₆H₂₈F₃N₃O₂
      Chemical formulaC₂₆H₂₈F₃N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥98% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      616521-10MGCN 04055977185256