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05-23-0600 Substance P - CAS 33507-63-0 - Calbiochem

Neuropeptide found in high concentrations in the gut.

Substance P - CAS 33507-63-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: RPKPQQFFGLM

Primary Target: Substance P receptors
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Overview

Key Spec Table

CAS #Empirical Formula
33507-63-0C₆₃H₉₈N₁₈O₁₃S

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      05230600-25MGCN
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          05230600-5MGCN
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              Description
              OverviewNeuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca2+ mobilization. Reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.
              Catalogue Number05-23-0600
              Brand Family Calbiochem®
              SynonymsRPKPQQFFGLM
              References
              ReferencesRoush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
              Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
              Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
              Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
              Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
              Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
              Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.
              Product Information
              CAS number33507-63-0
              ATP CompetitiveN
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₆₃H₉₈N₁₈O₁₃S
              Chemical formulaC₆₃H₉₈N₁₈O₁₃S
              Hygroscopic Hygroscopic
              ReversibleN
              Sold on the basis of peptide contentY
              Quality LevelMQ100
              Biological Information
              Primary TargetSubstance P receptors
              Purity≥96% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide ContentY
              Peptide SequenceH-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Global Trade Item Number
              Catalogue Number GTIN
              05230600-1MGCN 04055977207019
              05230600-25MGCN 04055977207026
              05230600-5MGCN 04055977207033