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573121 SMER28 - CAS 307538-42-7 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
307538-42-7C₁₁H₁₀BrN₃

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573121-10MGCN
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      Description
      OverviewA cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
      Catalogue Number573121
      Brand Family Calbiochem®
      Synonyms(6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
      References
      ReferencesTian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331.
      Product Information
      CAS number307538-42-7
      FormPale yellow solid
      Hill FormulaC₁₁H₁₀BrN₃
      Chemical formulaC₁₁H₁₀BrN₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      573121-10MGCN 04055977266054