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523310 Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem

A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, antiproliferative, and hypoglycemic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: trans-3,5-Dimethoxy-4ʹ-hydroxystilbene

Primary Target: COX-1 and COX-2 activities
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523310
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
537-42-8C₁₆H₁₆O₃

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      Description
      OverviewA cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC50 = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC50 = 70 µM), prevents DMBA-induced preneoplastic lesions (ED50 = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.
      Catalogue Number523310
      Brand Family Calbiochem®
      Synonymstrans-3,5-Dimethoxy-4ʹ-hydroxystilbene
      References
      ReferencesRoberti, M., et al. 2003. J. Med. Chem. 46, 3546.
      Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
      Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.
      Product Information
      CAS number537-42-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₁₆O₃
      Chemical formulaC₁₆H₁₆O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1 and COX-2 activities
      Primary Target IC<sub>50</sub>19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      523310-10MGCN 04055977271485

      Documentation

      Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pterostilbene, Pterocarpus marsupium - CAS 537-42-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      523310

      References

      Reference overview
      Roberti, M., et al. 2003. J. Med. Chem. 46, 3546.
      Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
      Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-October-2007 JSW
      Synonymstrans-3,5-Dimethoxy-4ʹ-hydroxystilbene
      DescriptionA cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox® (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC50 = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC50 = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED50 = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number537-42-8
      Chemical formulaC₁₆H₁₆O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesRoberti, M., et al. 2003. J. Med. Chem. 46, 3546.
      Rimando, A.M., et al. 2002. J. Agric. Food Chem. 50, 3453.
      Manickam, M., et al. 1997. J. Nat. Prod. 60, 609.