506155 Sigma-AldrichPifithrin-μ - CAS 64984-31-2 - Calbiochem
Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
More>> Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Less<<Synonyms: Phenylacetylenylsulfonamide, Hsp70 Inhibitor I
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Overview
Key Spec Table
CAS # | Empirical Formula |
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64984-31-2 | C₈H₇NO₂S |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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506155-10MGCN |
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Plastic ampoule | 10 mg |
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Description | |
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Overview | A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions. |
Catalogue Number | 506155 |
Brand Family | Calbiochem® |
Synonyms | Phenylacetylenylsulfonamide, Hsp70 Inhibitor I |
References | |
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References | Leu, J., et al. 2009. Mol. Cell 36, 15. Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474. |
Product Information | |
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CAS number | 64984-31-2 |
ATP Competitive | N |
Form | Off-white solid |
Hill Formula | C₈H₇NO₂S |
Chemical formula | C₈H₇NO₂S |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | p53 interaction with Bcl-xL and Bcl-2 proteins |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
506155-10MGCN | 04055977272253 |