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506155 Pifithrin-μ - CAS 64984-31-2 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
64984-31-2C₈H₇NO₂S

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506155-10MGCN
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      Description
      OverviewA cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
      Catalogue Number506155
      Brand Family Calbiochem®
      SynonymsPhenylacetylenylsulfonamide, Hsp70 Inhibitor I
      References
      ReferencesLeu, J., et al. 2009. Mol. Cell 36, 15.
      Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474.
      Product Information
      CAS number64984-31-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₈H₇NO₂S
      Chemical formulaC₈H₇NO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
      Biological Information
      Primary Targetp53 interaction with Bcl-xL and Bcl-2 proteins
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      506155-10MGCN 04055977272253