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524400 Phorbol-12-myristate-13-acetate - CAS 16561-29-8 - Calbiochem

Phorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PMA, TPA, PKC Activator I

Primary Target: Protein Kinase C
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524400
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Overview

Key Spec Table

CAS #Empirical Formula
16561-29-8C₃₆H₅₆O₈

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524400-10MGCN
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      524400-1MGCN
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          524400-25MGCN
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              524400-5MGCN
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                  Description
                  OverviewMost commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro, even at nM concentrations. Promotes the expression of inducible NOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible. Also available as a 10 mM solution in DMSO (Cat. No. 500582).
                  Catalogue Number524400
                  Brand Family Calbiochem®
                  SynonymsPMA, TPA, PKC Activator I
                  References
                  ReferencesPowell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
                  Tepper, C.G., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 8443.
                  Oishi, K., and Yamaguchi, M. 1994. J. Cell. Biochem. 55, 168.
                  Macfarlane, D.E., and O’Donnell, P.S. 1993. Leukemia 7, 1846.
                  Ghandi, V.C. and Jones, D.J., 1992. Neuropharmacol. 31, 1101.
                  Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
                  Kontny, E., et al. 1992. Eur. J. Pharmacol. 227, 333.
                  Zanaboni, P.B., et al. 1992. J. Appl. Physiol. 73, 2011.
                  Saltis, J., et al. 1991. J. Biol. Chem. 266, 261.
                  Beguinot, L., et al. 1985. Proc. Natl. Acad. Sci. USA 82, 2774.
                  Perchellet, J. 1985. Carcinogenesis 6, 567.
                  Nishizuka, Y. 1984. Science 255, 1365.
                  Mastro, A. 1982. Lymphokines 6, 263.
                  Product Information
                  CAS number16561-29-8
                  ATP CompetitiveN
                  FormWhite solid
                  Hill FormulaC₃₆H₅₆O₈
                  Chemical formulaC₃₆H₅₆O₈
                  ReversibleY
                  Structure formula ImageStructure formula Image
                  Quality LevelMQ100
                  Applications
                  ApplicationPhorbol-12-myristate-13-acetate, CAS 16561-29-8, acts as an extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro at nM concentrations.
                  Biological Information
                  Primary TargetProtein Kinase C
                  Purity≥98% by HPLC
                  Physicochemical Information
                  Cell permeableN
                  Safety Information according to GHS
                  RTECSQH4377000
                  Safety Information
                  R PhraseR: 21-38

                  Harmful in contact with skin.
                  Irritating to skin.
                  S PhraseS: 26-27-36-45

                  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
                  Take off immediately all contaminated clothing.
                  Wear suitable protective clothing.
                  In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
                  Storage and Shipping Information
                  Ship Code Ambient Temperature Only
                  Toxicity Harmful
                  Storage -20°C
                  Do not freeze Ok to freeze
                  Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Anhydrous DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
                  Packaging Information
                  Packaged under inert gas Packaged under inert gas
                  Global Trade Item Number
                  Catalogue Number GTIN
                  524400-10MGCN 04055977270952
                  524400-1MGCN 04055977270945
                  524400-25MGCN 04055977270969
                  524400-5MGCN 04055977270976