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516483 Pepstatin A, Penetratin - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₁₃₈H₂₂₉N₃₉O₂₈S

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516483-1MGCN
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      Description
      OverviewA Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
      Catalogue Number516483
      Brand Family Calbiochem®
      SynonymsPepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
      References
      ReferencesZaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243.
      Product Information
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Chemical formulaC₁₃₈H₂₂₉N₃₉O₂₈S
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide SequencePepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      516483-1MGCN 04055977198843