516483 Sigma-AldrichPepstatin A, Penetratin - Calbiochem
A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays.
More>> A Pepstatin A that is ~75% less potent against Cathespins D/E than PepA in cell-free assays. Less<<Synonyms: PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈
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Overview
Key Spec Table
Empirical Formula |
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C₁₃₈H₂₂₉N₃₉O₂₈S |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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516483-1MGCN |
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Plastic ampoule | 1 mg |
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Description | |
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Overview | A Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells. |
Catalogue Number | 516483 |
Brand Family | Calbiochem® |
Synonyms | PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp₄₃₋₅₈ |
References | |
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References | Zaidi, N., et al. 2007. Biochem. Biophys. Res. Commun. 364, 243. |
Product Information | |
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Form | White lyophilized solid |
Formulation | Supplied as a trifluoroacetate salt. |
Hill Formula | C₁₃₈H₂₂₉N₃₉O₂₈S |
Chemical formula | C₁₃₈H₂₂₉N₃₉O₂₈S |
Hygroscopic | Hygroscopic |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥97% by HPLC |
Physicochemical Information | |
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Peptide Sequence | PepA-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-CO₂H |
Safety Information | |
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S Phrase | S: 22-24/25 Do not breathe dust. Avoid contact with skin and eyes. |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
516483-1MGCN | 04055977198843 |