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14-844M PIP5K1α Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant human PIP5K1α, full length. For use in Kinase Assays.

PIP5K1α Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-844M
250 µg  Also available in 10 μg size (cat#14-844) and in bulk (cat# 14-844-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-844M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPIP5K1α Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant human PIP5K1α, full length.
      References
      Product Information
      Presentation10µg of enzyme in 50mM Tris/HCl pH8.0, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant human PIP5K1α, full length. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryParticipates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2 (By similarity)
      Gene Symbol
      • PIP5K1A
      Protein TargetPIP5K1α
      Purification MethodImmobilized metal affinity chromatography (IMAC)
      Target Sub-FamilyPIPK
      UniProt Number
      UniProt SummaryFUNCTION: Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2
      CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
      SUBUNIT STRUCTURE: Interacts with ARF1, RAC1, PLD1, PLD2 and JUB
      SUBCELLULAR LOCATION: Cell membrane. Endomembrane system. Golgi apparatus › Golgi stack. Note: Associated with the plasma membrane and with internal membranes. Associated with Golgi stacks. Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor.
      TISSUE SPECIFICITY: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.
      SIMILARITY: Contains 1 PIPK domain.
      Molecular Weight60kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in the PIProfiler.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-844) and in bulk (cat# 14-844-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-844M 04053252669231

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-844 PIP5K1α Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases