480404 Sigma-AldrichNFAT Inhibitor, MCV1 - Calbiochem
The NFAT Inhibitor, MCV1 controls the biological activity of NFAT.
More>> The NFAT Inhibitor, MCV1 controls the biological activity of NFAT. Less<<NFAT Inhibitor, MCV1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Maleimido-conjugated VIVIT 1, MPB-HPVIVIT, Maleimido-conjugated HPVIVIT
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Overview
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Key Spec Table
| Empirical Formula |
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| C₅₁H₇₅N₁₀O₁₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 480404-2MGCN |
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Glass bottle | 2 mg |
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| Description | |
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| Overview | A cell-permeable, synthetic maleimido-conjugated VIVIT motif peptide (HPVIVIT) that acts as a potent bipartite inhibitor of Nuclear factor of activated T-cells (NFAT) (IC50 = 62 nM). Blocks NFAT-calcineurin interaction by targeting two separate calcineurin docking motifs. Completely blocks NFAT dephosphorylation at 1 mM. Determined to be more potent that Cyclosporine A (Cat. No. 239835) and VIVIT peptide (MAGPHPVIVITGPHEE) in blocking NFAT activity. Also shown to blocks NFAT-mediated T-cell activation and vascular smooth muscle cell proliferation, thereby reducing neoimtima (new thickening of arterial wall) formation in mouse models of restenosis (repeat blocking of blood vessels). The biological half life of MCV1 has been estimated to be about 36 hours in COS-1 cells. |
| Catalogue Number | 480404 |
| Brand Family | Calbiochem® |
| Synonyms | Maleimido-conjugated VIVIT 1, MPB-HPVIVIT, Maleimido-conjugated HPVIVIT |
| References | |
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| References | Yu, H., et al. 2012. Circulation Res. 110, 200. |
| Product Information | |
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| Form | White solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₅₁H₇₅N₁₀O₁₂ |
| Chemical formula | C₅₁H₇₅N₁₀O₁₂ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Dimensions |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 480404-2MGCN | 04055977201338 |
Documentation
NFAT Inhibitor, MCV1 - Calbiochem SDS
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NFAT Inhibitor, MCV1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 480404 |
References
| Reference overview |
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| Yu, H., et al. 2012. Circulation Res. 110, 200. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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