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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
481480-1MGCN
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      Plastic ampoule 1 mg
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      481480-500UGCN
      Limited Availability
Limited Availability
      In Stock 
      Discontinued
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        Remaining : Will advise
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          Plastic ampoule 500 μg
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          Description
          OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
          Catalogue Number481480
          Brand Family Calbiochem®
          SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
          References
          ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
          Product Information
          ATP CompetitiveN
          DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Biological Information
          Primary Targettranslocation of the NF-κB active complex into the nucleus
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide ContentY
          Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
          Global Trade Item Number
          Catalogue Number GTIN
          481480-1MGCN 04055977183771
          481480-500UGCN 04055977183788