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FCMAB337F Milli-Mark™ Anti-Myelin Associated Glycoprotein-FITC Antibody, clone 513

This Milli-Mark Anti-Myelin Associated Glycoprotein-FITC Antibody, clone 513 is validated for use in FC for the detection of Myelin Associated Glycoprotein.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: MAG, SIGLEC4A, SIGLEC-4A, Siglec-4a, S-MAG, GMA UniProt Number: P07722
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FCMAB337F
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB337F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-Myelin Associated Glycoprotein-FITC Antibody, clone 513
      Alternate Names
      • Brain neuron cytoplasmic protein 3
      • Sialic acid-binding Ig-like lectin 4a
      • Siglec-4a
      • MAG
      Background InformationMyelin-associated glycoprotein (MAG), a member of the immunoglobulin superfamily, is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin; Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS.
      Product Information
      FormatFITC
      Control
      • B35 cells
      PresentationPurified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA
      Quality LevelMQ100
      Applications
      ApplicationThis Milli-Mark Anti-Myelin Associated Glycoprotein-FITC Antibody, clone 513 is validated for use in FC for the detection of Myelin Associated Glycoprotein.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenL2 epitope carrying glycoprotein extract of 1-2 old day chicken brain.
      Clone513
      HostMouse
      SpecificityAntibody recognizes Myelin Associated Glycoprotein.
      IsotypeIgG1
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
      Gene Symbol
      • MAG
      • SIGLEC4A
      • SIGLEC-4A
      • Siglec-4a
      • S-MAG
      • GMA
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P20916 # Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid (By similarity).

      SIZE: 626 amino acids; 69069 Da

      SUBUNIT: Binds to RTN4R (By similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      SIMILARITY: SwissProt: P20916 ## Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 4 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight 69.3 kDa Calculated
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using B35 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB337F 04053252630316