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FCMAB196P Milli-Mark™ Anti-CD42b-PE Antibody, clone AN51

This Milli-Mark Anti-CD42b-PE Antibody, clone AN51 is validated for use in FC for the detection of CD42b.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P07359
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FCMAB196P
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMPhycoerythrinMonoclonal Antibody
      Description
      Catalogue NumberFCMAB196P
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CD42b-PE Antibody, clone AN51
      Alternate Names
      • Platelet glycoprotein Ib alpha chain
      • Glycoprotein Ibalpha
      • GP-Ib alpha
      • GPIb-alpha
      • GPIbA
      • Antigen CD42b-alpha
      Background InformationCD42b is a 145 kDa protein, which together with CD42c forma a 160 kDa heterodimer composed of an alpha-chain and a beta-chain, respectively. The subunits are linked together by a disulphide bond. CD42b and CD42c forms a non-covalent complex together with CD42a and CD42d in the platelet plasma membrane. The CD42 complex serves as a receptor for von Willebrand factor and thrombin and mediates adhesion of platelets to subendothelial matrices (exposed upon damage to the endothelium) at high shear rates. The binding sites for von Willebrand factor and thrombin lies on CD42b (de Haas, 2002). CD42 is expressed on megakarytocytes and platelets (McMichael, 1981).
      References
      Product Information
      FormatPhycoerythrin
      Control
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG2a conjugated to PE in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis Milli-Mark Anti-CD42b-PE Antibody, clone AN51 is validated for use in FC for the detection of CD42b.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenMixture of human platelets and lymphocytes.
      CloneAN51
      HostMouse
      SpecificityAntibody recognizes Human CD42b antigen.
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryGlycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryGP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Genetic variations in GP1BA may be a cause of susceptibility to nonarteritic anterior ischemic optic neuropathy (NAION); also known as susceptibility to anterior ishcemic optic neuropathy (AION). AION involves loss of vision due to damage to the optic nerve from insufficient blood supply. AION is generally divided into two types: arteritic AION and NAION. NAION probably results from minute infarctions of the optic nerve caused by occlusion of the posterior ciliary arteries. Hypercholesterolemia, diabetes mellitus, ischemic heart disease, hyperhomocysteinemia, hypertension, and crowded disk have been implicated as predisposing conditions.

      Defects in GP1BA are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. Defects in GP1BA are the cause of benign mediterranean macrothrombocytopenia (BMM); also known as autosomal dominant benign Bernard-Soulier syndrome. BMM is characterized by mild or no clinical symptoms, normal platelet function, and normal megakaryocyte count.

      Defects in GP1BA are a cause of von Willebrand disease (vWD); also known as platelet-type von Willebrand disease or pseudo-von Willebrand disease (pseudo-vWD). This autosomal dominant bleeding disorder is caused by an increased affinity of GP-Ib for soluble vWF resulting in impaired hemostatic function due to the removal of vWF from the circulation.
      Molecular Weight 145 kDa (de Haas, 2002)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using human lymphocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB196P 04053252480331

      Documentation

      Milli-Mark™ Anti-CD42b-PE Antibody, clone AN51 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark™ Anti-CD42b-PE Antibody, clone AN51 Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CD42b-PE, clone AN51 - 2026022 2026022
      Milli-Mark Anti-CD42b-PE, clone AN51 - 2080868 2080868
      Milli-Mark Anti-CD42b-PE, clone AN51 - 2196074 2196074
      Milli-Mark Anti-CD42b-PE, clone AN51 - 2266753 2266753
      Milli-Mark Anti-CD42b-PE, clone AN51 - NRG1774109 NRG1774109
      Milli-Mark™ Anti-CD42b-PE, -2543759 2543759
      Milli-Mark™ Anti-CD42b-PE, -2688616 2688616
      Milli-Mark™ Anti-CD42b-PE, clone AN51 - 3192075 3192075
      Milli-Mark™ Anti-CD42b-PE, clone AN51 - 3383090 3383090
      Milli-Mark™ Anti-CD42b-PE, clone AN51 - 3613007 3613007
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