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FCMAB302F Milli-Mark™ Anti-Brachyury-FITC Antibody, clone 3E4.2

Milli-Mark Anti-Brachyury-FITC Antibody, clone 3E4.2 is an antibody against Brachyury for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Mesenchymal Stem Cells Gene Symbol: MGC104817, OTTHUMP00000017588, TF, TFT UniProt Number: O15178
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FCMAB302F
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB302F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-Brachyury-FITC Antibody, clone 3E4.2
      Alternate Names
      • T brachyury (mouse) homolog
      • T brachyury-like
      • T protein
      • T, brachyury homolog (mouse)
      • transcription factor T
      Background InformationThe Brachyury protein is a T-box transcription factor that is one of the earliest indicators of mesoderm formation during embryonic development. As the brachyury protein family is essential for the formation of the posterior body in all vertebrates, Brachyury has been shown to be expressed during gastrula and neurula stages, as well as in the developing notochord. Consequently, when mutations occur within the brachyury gene, severe vertebral malformations have been found to occur, as a direct result. In addition, current findings also indicate that the dysregulation of brachyury may also be linked to the formation of chordomas, which are malignant tumors that develop along the spine.
      Product Information
      FormatFITC
      Control
      • mouse ES cells (CMTI-2)
      PresentationPurified mouse monoclonal IgG1k conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
      Quality LevelMQ100
      Applications
      ApplicationMilli-Mark Anti-Brachyury-FITC Antibody, clone 3E4.2 is an antibody against Brachyury for use in FC.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenSynthetic human brachyury peptide, a.a. 224-435.
      Clone3E4.2
      HostMouse
      SpecificityAntibody recognizes Brachyury.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.
      Gene Symbol
      • MGC104817
      • OTTHUMP00000017588
      • TF
      • TFT
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15178 # Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.

      SIZE: 435 amino acids; 47443 Da

      SUBUNIT: Monomer (By similarity).

      Nucleus.

      DISEASE: SwissProt: O15178 # Genetic variations in T are associated with susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis.

      SIMILARITY: SwissProt: O15178 ## Contains 1 T-box DNA-binding domain. ...
      Molecular Weight 47 kDa Calculated
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using mouse ES cells (CMTI-2)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB302F 04053252681363