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444287 MMP-13, Human, Recombinant, Active

MMP-13, Human, Recombinant, Active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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444287
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Overview

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444287-5UGCN
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      		 Plastic ampoule 5 μg
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      Description
      OverviewRecombinant, human MMP-13. MMP-13 is a collagenase-3 enzyme that degrades a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X, and XIV, gelatin, aggrecan, perlecan and fibronectin. It is distinguished from other human collagenases by the fact that it effectively degrades type II collagen. The importance of MMP-13 is further strengthened by reports that it is a biomarker for poor prognosis in many carcinomas and other type of cancers.
      Catalogue Number444287
      Brand Family Calbiochem®
      References
      ReferencesFreije, M.P.S., et al. 1994. J. Biol. Chem. 269,16766.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of APMA-activated enzyme that will hydrolyze 1µmol MCA-Pro-Leu-Lys-Gly-Leu-DPA-Ala-Arg-NH₂ (Cat. No. 03-32-5032) at 37°C, pH 7.5.
      FormLiquid
      FormulationIn 50 mM HEPES, 10 mM CaCl₂, 20% glycerol, 0.005% BRIJ® 35 Detergent, pH 7.5. APMA-free.
      Quality LevelMQ100
      Applications
      Biological Information
      Specific Activity≥50 mU/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444287-5UGCN 04055977186048

      Documentation

      MMP-13, Human, Recombinant, Active SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-13, Human, Recombinant, Active Certificates of Analysis

      TitleLot Number
      444287

      References

      Reference overview
      Freije, M.P.S., et al. 1994. J. Biol. Chem. 269,16766.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-March-2009 JSW
      DescriptionRecombinant, human MMP-13. MMP-13 is a collagenase-3 enzyme that degrades a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X, and XIV, gelatin, aggrecan, perlecan and fibronectin. It is distinguished from other human collagenases by the fact that it effectively degrades type II collagen. The importance of MMP-13 is further strengthened by reports that it is a biomarker for poor prognosis in many carcinomas and other type of cancers.
      FormLiquid
      FormulationIn 50 mM HEPES, 10 mM CaCl₂, 20% glycerol, 0.005% BRIJ® 35 Detergent, pH 7.5. APMA-free.
      Concentration Label Please refer to vial label for lot-specific concentration
      Specific activity≥50 mU/mg protein
      Unit definitionOne unit is defined as the amount of APMA-activated enzyme that will hydrolyze 1µmol MCA-Pro-Leu-Lys-Gly-Leu-DPA-Ala-Arg-NH₂ (Cat. No. 03-32-5032) at 37°C, pH 7.5.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesFreije, M.P.S., et al. 1994. J. Biol. Chem. 269,16766.