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475837 MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

MIF Antagonist, ISO-1, CAS 478336-92-4, is a cell-permeable inhibitor of MIF tautomerase (IC50 = 7 µM for D-dopachrome tautomerase). Suppresses the production of TNFα, PGE2 & COX-2 in monocytes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1

Primary Target: MIF tautomerize
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475837
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
478336-92-4C₁₂H₁₃NO₄

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      Description
      OverviewA cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. Also available as a 50 mM solution in DMSO (Cat. No. 505225).
      Catalogue Number475837
      Brand Family Calbiochem®
      Synonyms(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
      References
      ReferencesCvetkovic, I., et al. 2005. Endocrinology, 146, 2942.
      Lubetsky, J.B., et al. 2002. J. Biol. Chem. 277, 24976.
      Product Information
      CAS number478336-92-4
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₁₂H₁₃NO₄
      Chemical formulaC₁₂H₁₃NO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMIF Antagonist, ISO-1, CAS 478336-92-4, is a cell-permeable inhibitor of MIF tautomerase (IC50 = 7 µM for D-dopachrome tautomerase). Suppresses the production of TNFα, PGE2 & COX-2 in monocytes.
      Biological Information
      Primary TargetMIF tautomerize
      Primary Target IC<sub>50</sub>7 µM for D-dopachrome tautomerase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475837-5MGCN 04055977184969

      Documentation

      MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      475837

      References

      Reference overview
      Cvetkovic, I., et al. 2005. Endocrinology, 146, 2942.
      Lubetsky, J.B., et al. 2002. J. Biol. Chem. 277, 24976.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      Synonyms(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
      DescriptionA cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF dopachrome tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number478336-92-4
      Chemical formulaC₁₂H₁₃NO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCvetkovic, I., et al. 2005. Endocrinology, 146, 2942.
      Lubetsky, J.B., et al. 2002. J. Biol. Chem. 277, 24976.