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420119 JNK Inhibitor II - CAS 129-56-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
129-56-6C₁₄H₈N₂O

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420119-25MGCN
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      420119-50MGCN
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          420119-5MGCN
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              Description
              OverviewA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
              Catalogue Number420119
              Brand Family Calbiochem®
              SynonymsAnthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II
              References
              ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
              Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
              Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
              Product Information
              CAS number129-56-6
              ATP CompetitiveY
              FormYellowish orange solid
              Hill FormulaC₁₄H₈N₂O
              Chemical formulaC₁₄H₈N₂O
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              ApplicationJNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).
              Biological Information
              Primary TargetJNK 1, JNK 2, JNK 3
              Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Safety Information according to GHS
              RTECSCB4585000
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Global Trade Item Number
              Catalogue Number GTIN
              420119-25MGCN 04055977187977
              420119-50MGCN 04055977187991
              420119-5MGCN 07790788050092