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341291 Fas/FasL Antagonist, Kp7-6 - Calbiochem

The Fas/FasL Antagonist, Kp7-6 controls the biological activity of Fas/FasL. This small molecule/inhibitor is primarily used for Cancer applications.

Fas/FasL Antagonist, Kp7-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6

Primary Target: Fas/FasL-mediated cellular apoptotic signals
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341291
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₈H₅₆N₁₀O₁₅S₂

Pricing & Availability

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341291-25MGCN
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      		 Plastic ampoule 25 mg
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      Description
      OverviewAn exocyclic cystine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling pathways. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.
      Catalogue Number341291
      Brand Family Calbiochem®
      SynonymsH-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6
      References
      ReferencesCarmona, E.M., et al. 2006. J. Immunol. 177, 459.
      Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 7,288,519.
      FormWhite lyophilized powder
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₈H₅₆N₁₀O₁₅S₂
      Chemical formulaC₄₈H₅₆N₁₀O₁₅S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFas/FasL-mediated cellular apoptotic signals
      Primary Target IC<sub>50</sub>Kd = 11.2 & 13.2 µM for FasL and Fas (CD95/APO-1), respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH₂N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO₂H, Cyclic [disulfide bond between Cys-Cys]
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      341291-25MGCN 04055977215618

      Documentation

      Fas/FasL Antagonist, Kp7-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Fas/FasL Antagonist, Kp7-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      341291

      References

      Reference overview
      Carmona, E.M., et al. 2006. J. Immunol. 177, 459.
      Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-January-2013 JSW
      SynonymsH-YC*DEHFC*Y-OH, Cyclic [Cys-Cys disulfide], Kp7-6
      DescriptionAn exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 µM, respectively), resulting in disabled receptor ensembles and altered signaling. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.
      FormWhite lyophilized powder
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₈H₅₆N₁₀O₁₅S₂
      Peptide SequenceH₂N-Tyr-Cys*-Asp-Glu-His-Phe-Cys*-Tyr-CO₂H, Cyclic [disulfide bond between Cys-Cys]
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCarmona, E.M., et al. 2006. J. Immunol. 177, 459.
      Hasegawa, A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 6599.