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344152 FPT Inhibitor II - Calbiochem

The FPT Inhibitor II controls the biological activity of FPT. This small molecule/inhibitor is primarily used for Cancer applications.

FPT Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na

Primary Target: Farnesyltransferase (Ftase)
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344152
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₂₈NO₅P • 2Na

Pricing & Availability

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      Description
      OverviewA cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number344152
      Brand Family Calbiochem®
      Synonyms(E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na
      References
      ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₇H₂₈NO₅P • 2Na
      Chemical formulaC₁₇H₂₈NO₅P • 2Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFarnesyltransferase (Ftase)
      Primary Target IC<sub>50</sub>75 nM against Ftase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344152-1MGCN 04055977215267

      Documentation

      FPT Inhibitor II - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FPT Inhibitor II - Calbiochem Certificates of Analysis

      TitleLot Number
      344152

      References

      Reference overview
      Manne, V., et al. 1995. Drug Development Res. 34, 121.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-March-2018 JSW
      Synonyms(E,E)-2-[2-Oxo-2-[[(3,7,11-trimethyl-2,6,10-dodecatrienyl)oxy]amino]ethyl]phosphonic Acid, 2Na
      DescriptionA highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 75 nM). Inhibits geranylgeranyltransferase I (IC50 = 24 µM) and II (IC50 = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.
      FormWhite solid
      Chemical formulaC₁₇H₂₈NO₅P • 2Na
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (≥10 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesManne, V., et al. 1995. Drug Development Res. 34, 121.