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341207 ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem

A cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells.

ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine

Primary Target: PI-PLC
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341207
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
70641-51-9C₂₇H₅₈NO₆P

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      Description
      OverviewA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells.
      Catalogue Number341207
      Brand Family Calbiochem®
      SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
      References
      ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
      Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
      Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
      Helfman, D., et al. 1993. Cancer Res. 53, 2955.
      Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
      Powis, G., et al. 1992. Cancer Res. 52, 2835.
      Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
      Product Information
      CAS number70641-51-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₇H₅₈NO₆P
      Chemical formulaC₂₇H₅₈NO₆P
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI-PLC
      Primary Target IC<sub>50</sub>9.6 µM against phosphatidylinositol-specific phospholipase C (PI-PLC)
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSYK0718000
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      341207-5MGCN 04055977215441

      Documentation

      ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      341207

      References

      Reference overview
      Harguindey, J., et al. 2000. Apoptosis 5, 87.
      Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
      Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
      Helfman, D., et al. 1993. Cancer Res. 53, 2955.
      Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
      Powis, G., et al. 1992. Cancer Res. 52, 2835.
      Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.

      Posters

      Title
      Human Kinome & InhibitorSelect™ Libraries
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-May-2011 JSW
      SynonymsEdelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine
      DescriptionA cell-permeable and reversible cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC, IC50 = 9.6 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Inhibits protein kinase C from various leukemic cells. Also promotes rapid and selective apoptosis in human leukemic cells. Has strong antitumor and anticancer properties.
      FormWhite solid
      CAS number70641-51-9
      RTECSYK0718000
      Chemical formulaC₂₇H₅₈NO₆P
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (5 mg/ml), CHCl₃ (50 mg/ml), Ethanol (5 mg/ml), or H₂O. Material may form micelles in aqueous stock solutions, which may affect experimental results.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solution; reconstitute just prior to use.
      Toxicity Carcinogenic / Teratogenic
      ReferencesHarguindey, J., et al. 2000. Apoptosis 5, 87.
      Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813.
      Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91.
      Helfman, D., et al. 1993. Cancer Res. 53, 2955.
      Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603.
      Powis, G., et al. 1992. Cancer Res. 52, 2835.
      Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.