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233501 Coagulation Factor XIII, Human Plasma

Coagulation Factor XIII, Human Plasma, CAS 9013-56-3, is a native tetrameric form composed of two identical α- and two β-subunits. Thrombin converts the α2β2 tetramer to a modified α2ʹβ2 tetramer.

Coagulation Factor XIII, Human Plasma MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fibrin-stabilizing Factor

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233501
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233501-100UGCN
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      Description
      OverviewNative coagulation factor XIII from human plasma. Plasma Factor XIII is a tetramer (α2β2) composed of two identical α-subunits and two identical β-subunits. After thrombin cleavage converts the α2β2 tetramer to a modified α2′β2 tetramer, Ca2+ promotes both the dissociation of the β2 dimer and the activation of the α2′ dimer to its catalytically active form. This activated Factor XIII (Factor XIIIa) strengthens the fibrin clot by catalyzing the formation of glutamyl-lysine bonds between fibrin monomers.
      Catalogue Number233501
      Brand Family Calbiochem®
      SynonymsFibrin-stabilizing Factor
      References
      Product Information
      CAS number9013-56-3
      Unit of DefinitionClotting activity is determined by comparison to a standard curve produced using normal pooled human plasma. One unit is defined as the activity in 1 ml of normal, pooled plasma.
      FormLiquid
      FormulationIn 500 µM EDTA, 50% glycerol.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥40 units/mg protein (clotting assay)
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      233501-100UGCN 04055977217872

      Documentation

      Coagulation Factor XIII, Human Plasma SDS

      Title

      Safety Data Sheet (SDS) 

      Coagulation Factor XIII, Human Plasma Certificates of Analysis

      TitleLot Number
      233501
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      SynonymsFibrin-stabilizing Factor
      DescriptionNative coagulation factor XIII from human plasma. Plasma Factor XIII is a tetramer (α2β2) composed of two identical α-subunits and two identical β-subunits. After thrombin cleavage converts the α2β2 tetramer to a modified α2'β2 tetramer, Ca2+ promotes both the dissociation of β2 dimer and the activation of the α2' dimer to its catalytically active form. This activated Factor XIII (Factor XIIIa) strengthens the fibrin clot by catalyzing the formation of glutamyl-lysine bonds between fibrin monomers.
      FormLiquid
      FormulationIn 500 µM EDTA, 50% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number9013-56-3
      Purity≥95% by SDS-PAGE
      Specific activity≥40 units/mg protein (clotting assay)
      Unit definitionClotting activity is determined by comparison to a standard curve produced using normal pooled human plasma. One unit is defined as the activity in 1 ml of normal, pooled plasma.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      Merck USA index14, 3926