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233165
Sigma-AldrichClioquinol - CAS 130-26-7 - Calbiochem
A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.
More>>A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Less<<
Clioquinol - CAS 130-26-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.
Catalogue Number
233165
Brand Family
Calbiochem®
Synonyms
5-Chloro-7-iodo-8-hydroxyquinoline
References
References
Melov, S. 2002. Trends Neurosci.25, 121. Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408. Helmuth, L., et al. 2000. Science290, 1273. Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.
May cause sensitization by inhalation and skin contact. Possible risk of harm to the unborn child.
S Phrase
S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
29-April-2008 RFH
Synonyms
5-Chloro-7-iodo-8-hydroxyquinoline
Description
A metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid's ability to clump together, apparently by trapping the Cu2+ and Zn2+ that reduces the build-up of these deposits. Exhibits greater affinity for Cu2+ and Zn2+ than for Ca2+ and Mg2+. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer's disease.
Form
Solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
130-26-7
RTECS
VC5075000
Chemical formula
C₉H₅ClINO
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (20 mg/ml), Ethanol (1 mg/ml) or Methanol (1.5 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic & Carcinogenic / Teratogenic
Merck USA index
14, 5031
References
Melov, S. 2002. Trends Neurosci.25, 121. Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord.12, 408. Helmuth, L., et al. 2000. Science290, 1273. Tateishi, J., et al. 2000. Neuropathology20, Suppl: S20-4.
