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208743 Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-L-Abu-CONH(CH₂)₃-morpholine

Primary Target: calpain 1, calpain 2
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208743
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Overview

Key Spec Table

CAS #Empirical Formula
145731-49-3C₂₆H₄₀N₄O₆

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      Description
      OverviewA cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
      Catalogue Number208743
      Brand Family Calbiochem®
      SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
      References
      ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
      DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
      Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
      Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
      Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
      James, T., et al. 1998. J. Neurosci. Res. 51, 218.
      Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
      Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Bartus, R.T., et al. 1994. Stroke 25, 2265.
      Product Information
      CAS number145731-49-3
      ATP CompetitiveN
      FormWhite to off-white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₂₆H₄₀N₄O₆
      Chemical formulaC₂₆H₄₀N₄O₆
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcalpain 1, calpain 2
      Primary Target K<sub>i</sub>140 nM and 41 nM, against calpain-1 and -2, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      208743-5MGCN 04055977202809