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189410 Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem

The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline

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189410
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
331771-20-1C₂₉H₃₁N₅O₄

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      Description
      OverviewA cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
      Catalogue Number189410
      Brand Family Calbiochem®
      Synonyms4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
      References
      ReferencesGadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
      Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.
      Product Information
      CAS number331771-20-1
      FormWhite solid
      Hill FormulaC₂₉H₃₁N₅O₄
      Chemical formulaC₂₉H₃₁N₅O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      189410-5MGCN 04055977221763

      Documentation

      Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aurora Kinase Inhibitor VI, ZM447439 - CAS 331771-20-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      189410

      References

      Reference overview
      Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
      Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.

      Brochure

      Title
      New Products: Volume 3, 2012
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2018 JSW
      Synonyms4-(4-(N-Benzoylamino)anilino)-6- methoxy-7-(3-(1-morpholino)propoxy)quinazoline
      DescriptionA cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50 = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50 = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC50 > 10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331771-20-1
      Chemical formulaC₂₉H₃₁N₅O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesGadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell 16, 1305.
      Ditchfield, C., et al. 2003. J. Cell Biol. 161, 267.