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05-1567 Anti-p120 Catenin Antibody, clone 15D2

Use Anti-p120 Catenin Antibody, clone 15D2 (mouse monoclonal antibody) validated in WB, ICC, FC to detect p120 Catenin also known as Cadherin-associated Src substrate ,catenin (cadherin-associated protein) delta 1.

Anti-p120 Catenin Antibody, clone 15D2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Transcription Factors Gene Symbol: CAS , CTNND, KIAA0384, P120CAS, p120, P120CTN, p120(cas), p120(ctn), p120cas , p120ctn UniProt Number: O60716
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05-1567
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICC, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number05-1567
      Replaces04-237
      DescriptionAnti-p120 Catenin Antibody, clone 15D2
      Alternate Names
      • Cadherin-associated Src substrate
      • catenin (cadherin-associated protein), delta 1
      • catenin, delta 1, p120 catenin
      Background Informationp120 Catenin is a cadherin-associated protein that binds intracellular proteins, such as the small GTPase, RhoA, and controls E-cadherin funcation and stability. Proteins of the p120 family and their isoforms are expressed in cells via alternative splicing, and all of them are essential for HGF signaling to Rac1.
      References
      Product Information
      FormatPurified
      Control
      • Hela cell lysate.
      PresentationPurified mouse monoclonal in 0.1M Tris-Glycine (pH 7.4), 150mM NaCl and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationUse Anti-p120 Catenin Antibody, clone 15D2 (mouse monoclonal antibody) validated in WB, ICC, FC to detect p120 Catenin also known as Cadherin-associated Src substrate ,catenin (cadherin-associated protein) delta 1.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Flow Cytometry
      Application NotesImmunocytochemistry:
      Biological Information
      ImmunogenRecombinant fusion protein derived from the C-terminus of murine p120
      EpitopeC-terminus
      Cloneclone 15D2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes p120 Catenin
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Species Reactivity NoteHuman and Mouse. Predicted to react with Rat based on homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CAS
      • CTNND
      • KIAA0384
      • P120CAS
      • p120
      • P120CTN
      • p120(cas)
      • p120(ctn)
      • p120cas
      • p120ctn
      Purification MethodProtein G Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway By similarity. May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

      SUBUNIT STRUCTURE: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2.

      SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membraneBy similarity. Note= Interaction with GLIS2 promotes nuclear translocation By similarity.

      TISSUE SPECIFICITY: Expressed in vascular endothelium.

      INDUCTION: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.

      DOMAIN: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.

      PTM: Phosphorylated By similarity.

      INVOLVEMENT IN DISEASE: May contribute to cell malignancy. Complete loss of expression was observed in approximately 10% of invasive ductal breast carcinomas investigated.

      SEQUENCE SIMILARITIES: Belongs to the beta-catenin family.

      Contains 10 ARM repeats.
      Molecular Weight90-120 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot on Hela cell lysate.
      Western Blot Analysis: 1 g/mL of this antibody detected p120 Catenin in lysate from Hela cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8ºC from date of receipt.
      Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      05-1567 04053252268724

      Documentation

      Anti-p120 Catenin Antibody, clone 15D2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-p120 Catenin Antibody, clone 15D2 Certificates of Analysis

      TitleLot Number
      Anti-p120 Catenin, clone 15D2 2393915
      Anti-p120 Catenin, clone 15D2 - 2110566 2110566
      Anti-p120 Catenin, clone 15D2 - 2145093 2145093
      Anti-p120 Catenin, clone 15D2 - 2291694 2291694
      Anti-p120 Catenin, clone 15D2 - 3282542 3282542
      Anti-p120 Catenin, clone 15D2 - 3552762 3552762
      Anti-p120 Catenin, clone 15D2 - 3700480 3700480
      Anti-p120 Catenin, clone 15D2 - 3896404 3896404
      Anti-p120 Catenin, clone 15D2 - NG1614435 NG1614435
      Anti-p120 Catenin, clone 15D2 - NG1840137 NG1840137
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