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AB10521 Anti-Neuropilin-1 Antibody

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AB10521
100 µL  
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      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, MWB, IHC, IP, IFRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB10521
      DescriptionAnti-Neuropilin-1 Antibody
      Alternate Names
      • CD304 antigen
      • Vascular endothelial cell growth factor 165 receptor
      • neuropilin 1
      • transmembrane receptor
      • Npn 1
      Background InformationNeuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. It is expected to form complexes with the plexinA subfamily members and mediate the semaphorin-elicited inhibitory signals into neurons. Third, in endothelial cells, neuropilin-1 binds a potent endothelial cell mitogen, vascular endothelial growth factor (VEGF)165, and regulates vessel formation.
      Product Information
      FormatSerum
      Control
      • PC12 cell lysate
      PresentationRabbit serum in buffer containing 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Neuropilin-1 Antibody is validated for use in WB, IH, IP, IF for the detection of Neuropilin-1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunoprecipitation
      • Immunofluorescence
      Biological Information
      ImmunogenThis antibody is generated from rabbits immunized with a His-tagged partial recombinant rat Neuropilin-1.
      EpitopeUnknown
      HostRabbit
      SpecificityThis antibody recognizes Neuropilin-1.
      IsotypeIgG
      Species Reactivity
      • Rat
      • Mouse
      Species Reactivity NoteProven to react with mouse and rat. Human-94% homology
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]
      Gene Symbol
      • NRP1
      • NRP
      • NP1
      • BDCA4
      • CD304
      • neuropilin-1
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).
      SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Found in the embryonic nervous system.
      SIMILARITY: Belongs to the neuropilin family.
      Contains 2 CUB domains.
      Contains 2 F5/8 type domains.
      Contains 1 MAM domain.
      Molecular Weight 130 kDa
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in PC12 cell lysate.
      Western Blot Analysis: : 1:1,000 dilution of this antibody detected Neuropilin 1 on 10 µg of PC12 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Catalogue Number GTIN
      AB10521 04053252365621