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ABN308 Anti-DISC1 Antibody

Anti-DISC1 detects levels of DISC1 proteins & has been published & validated for use in IHC, ICC & WB.

Anti-DISC1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: DISC1 UniProt Number: Q9NRI5
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ABN308
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R, MIHC, ICC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN308
      DescriptionAnti-DISC1 Antibody
      Alternate Names
      • Disrupted in schizophrenia 1
      Background InformationDisrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human brain tissue
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-DISC1 detects levels of DISC1 proteins & has been published & validated for use in IHC, ICC & WB.
      Key Applications
      • Immunohistochemistry
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in rat cerebellum tissue.

      Immunocytochemistry Analysis: A 1:2,000 dilution from a representative lot detected DISC1 in HeLa cells.

      Western Blot Analysis: 2 µg/mL from a representative lot detected DISC1 in 10 µg/mL of SK-N-SH cell lysate and mouse brain tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human DISC1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • DISC1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~94 kDa observed. Uniprot describes 8 isoforms ranging between ~39 kDa and ~94 kDa; however, there are many additional isoforms of DISC1 known to exist. (Ishizuka, K., et al. (2007). Molecular Psychiatry. 12:897-899.)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human brain tissue.

      Immunohistochemistry Analysis: A 1:2,000 dilution of this antibody lot detected DISC1 in human brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN308 04053252831058

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies