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AB3402P Anti-Agouti Related Protein Antibody

Detect Agouti Related Protein using this Anti-Agouti Related Protein Antibody validated for use in ELISA & WB.

Anti-Agouti Related Protein Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Glucose/Glycogen Metabolism Gene Symbol: AGRP, Agrt, ASIP2, MGC118963, AGRT, ART UniProt Number: O00253
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AB3402P
50 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3402P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Agouti Related Protein Antibody
      Alternate Names
      • AGRP
      Background InformationAgouti-related peptide-expressing (AgRP) neurons seem to be critical for the acute regulation of eating. The AgRP protein is a strong antagonis of MC3-R and MC4-R and is expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
      Product Information
      FormatAffinity Purified
      PresentationLiquid in phosphate buffered saline containing 0.1% BSA.
      Quality LevelMQ100
      Applications
      ApplicationDetect Agouti Related Protein using this Anti-Agouti Related Protein Antibody validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL.



      ELISA: 1:10,000-1:50,000 using 50-100 ng control peptide per well.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 15 amino acid peptide near the C-terminus of mouse AGRP (Shutter et al. 1997; Ollmann et al. 1997).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes AGRP. The immunogen shows no significant sequence homology with Agouti, tubby, tub, TULP1 or TULP2.

      SPECIES REACTIVITIES: The immunogen sequence is 85% homologous with human and bovine. Reactivity with other species has not been confirmed.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAgouti-related protein is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation. Agouti-related protein is alternatively spliced into 2 variants which differ in 5' untranslated sequence length.
      Gene Symbol
      • AGRP
      • Agrt
      • ASIP2
      • MGC118963
      • AGRT
      • ART
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O00253 # Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.
      SIZE: 132 amino acids; 14440 Da
      SUBCELLULAR LOCATION: Secreted (By similarity).
      TISSUE SPECIFICITY: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
      DOMAIN: SwissProt: O00253 The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
      DISEASE: SwissProt: O00253 # Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].
      SIMILARITY: Contains 1 agouti domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Global Trade Item Number
      Catalogue Number GTIN
      AB3402P 04053252401688