124011 Sigma-AldrichAkt Inhibitor IV - CAS 681281-88-9 - Calbiochem
Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
More>> Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 681281-88-9 | C₃₁H₂₇IN₄S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 124011-1MGCN |
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Glass bottle | 1 mg |
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| 124011-5MGCN |
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Plastic ampoule | 5 mg |
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| Description | |
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| Overview | A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available. |
| Catalogue Number | 124011 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
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| CAS number | 681281-88-9 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₃₁H₂₇IN₄S |
| Chemical formula | C₃₁H₂₇IN₄S |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 124011-1MGCN | 04055977206357 |
| 124011-5MGCN | 04055977205626 |
Documentation
Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 124011 |
References
| Reference overview |
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| Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
Brochure
| Title |
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| Akt |
| Biologics 31.1 |
Posters
| Title |
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| Human Kinome & InhibitorSelect™ Libraries |
Citations
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| Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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