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658452
Sigma-AldrichAG 126 - CAS 118409-62-4 - Calbiochem
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.
More>>A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Less<<
AG 126 - CAS 118409-62-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
Catalogue Number
658452
Brand Family
Calbiochem®
Synonyms
α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
References
References
Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138. Kan, H., et al. 1996. Mol. Pharmacol.50, 1139. Novogrodsky, A., et al. 1994. Science264, 1319.
15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
Purity
≥95% by HPLC
Physicochemical Information
Cell permeable
Y
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R Phrase
R: 23/24/25
Toxic by inhalation, in contact with skin and if swallowed.
S Phrase
S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
-20°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
AG 126 - CAS 118409-62-4 - Calbiochem Certificates of Analysis
Title
Lot Number
658452
References
Reference overview
Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138. Kan, H., et al. 1996. Mol. Pharmacol.50, 1139. Novogrodsky, A., et al. 1994. Science264, 1319.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
04-January-2010 RFH
Synonyms
α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
Description
A cell-permeable inhibitor of lipopolysaccaride (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate.
Form
Yellow solid
CAS number
118409-62-4
Chemical formula
C₁₀H₅N₃O₃
Structure formula
Purity
≥95% by HPLC
Solubility
DMF or DMSO (5 mg/ml)
Storage
Protect from light -20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity
Toxic
References
Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145. Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138. Kan, H., et al. 1996. Mol. Pharmacol.50, 1139. Novogrodsky, A., et al. 1994. Science264, 1319.
