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219330 β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem

The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide

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219330
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
108409-83-2C₁₃H₁₀Cl₂N₂O₄S

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219330-10MGCN
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      Description
      OverviewA cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
      Catalogue Number219330
      Brand Family Calbiochem®
      SynonymsWnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
      References
      ReferencesHandeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.
      Product Information
      CAS number108409-83-2
      FormYellow solid
      Hill FormulaC₁₃H₁₀Cl₂N₂O₄S
      Chemical formulaC₁₃H₁₀Cl₂N₂O₄S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      219330-10MGCN 04055977202090

      Documentation

      β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      219330

      References

      Reference overview
      Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      SynonymsWnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
      DescriptionA cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number108409-83-2
      Chemical formulaC₁₃H₁₀Cl₂N₂O₄S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHandeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521.