565740 Sigma-Aldrichα-Amyloid Precursor Protein Modulator - CAS 497259-23-1 - Calbiochem
A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas
More>> A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam, PKC Activator V
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 497259-23-1 | C₂₇H₃₀F₃N₃O₃ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 565740-1MGCN |
|
Plastic ampoule | 1 mg |
|
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| References | |
|---|---|
| References | Kozikowski, A.P., et al. 2003. J. Med. Chem. 46, 364. |
| Product Information | |
|---|---|
| CAS number | 497259-23-1 |
| ATP Competitive | N |
| Form | Orange solid |
| Hill Formula | C₂₇H₃₀F₃N₃O₃ |
| Chemical formula | C₂₇H₃₀F₃N₃O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | PKC |
| Primary Target K<sub>i</sub> | 11.9 nM for activating PKCα |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 565740-1MGCN | 04055977267648 |